The year is 1961, and Poplar is beginning to feel the winds of social change alongside improvements in housing, sanitation and healthcare. But for the midwives and nuns of Nonnatus House, it’s business as usual, as they continue to care for the sick and bring new life into the world. The personal and professional lives of the nurses remain entwined, as events in their work impact on their personal choices.
Across the series, the midwives encounter complex and challenging cases from an outbreak of typhoid, to the increase in lung cancer, a teenage pregnancy and a mother who vanishes. But all are rocked when two babies with severe deformities are born, several months apart. As they struggle to understand why, they must find ways to deal with the resulting medical and emotional fallout.